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doi: 10.1155/2018/5489476

The healing crisis and detox symptoms are not generally a sign you need a reduced dose

We believe this is a main reason for the reports of painful treatments

Daratumumab depletes CD38+ immune regulatory cells, promotes T-cell expansion, and skews T-cell repertoire in multiple myeloma
Isolation of a cDNA encoding the human CD38 (T10) molecule, a cell surface glycoprotein with an unusual discontinuous pattern of expression during lymphocyte differentiation
