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GSHCbl is a newly proposed active form of B 12 , a cofactor affecting nitric oxide production, protection, and action in reactions associated with cell membranes.34,35 Those effects may have profound implications for vascular and immune health, but the results of those studies are preliminary.3639 Supplementation with AdCbl has been shown to modulate the immune response by downregulating excess inflammatory processes that are mediated by inducible nitric oxide.37 That fact may explain why B 12 supplementation has been shown to reduce the severity of autoimmune conditions, such as rheumatoid40 and atopic dermatitis.41 It is likely that all forms of B 12 may have those effects, because they are all converted to intracellular GSHCbl

& Kapoor, M

Leaky gut syndrome, in particular, is characterized by increased permeability in the intestinal lining, which can lead to a host of other health issues, including autoimmune diseases

This study was reviewed and approved by the University of Washington Institutional Animal Care and Use Committee (IACUC)

Research shows Dihexa treatment increases expression of synaptophysin and other synaptic markers even in disease models characterized by synaptic degeneration