glutathione metabolism genes Apoptosis and glutathione: beyond an antioxidant Identification of glutathione metabolism-related hub

Proteins were diluted in running buffer at 100 nM (equimolar E2 monomer) and association and dissociation were measured for 300 s

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discovered that p53 could promote the ubiquitination and subsequent proteasomal degradation of FLIP in response to cisplatin treatment, leading to the apoptosis of OC cells, potentially improving the therapeutic effects of cisplatin on OC

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Furthermore, AQ-QI- and DEAQ-QI-induced cytotoxicity was reduced in GSTP1 -transfected cells under GSH-depleted conditions