igf-1 lr3 long term effects Late-life targeting of the receptor improves healthspan and lifespan in female mice The IGF-1 Trade-Off: Performance vs.
Description
Combination-therapy models: Evaluating interactions with GLP-1 receptor agonists (e.g., semaglutide) to study additive or complementary effects on appetite and metabolism

The NHS confirms this

During their study, it was found that though transgenic lines did not show much phenotypic difference when grown in soil rite, whenseeds were germinated on half-strength MS media, then during the growth of the seedling, increased root length was observed for the transgenic lines as compared to the wild type

Appetite changes Some community users report appetite changes, though food intake was not significantly altered in the DIO mouse studies

Think of it as a seesaw