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There is no good evidence for a B12 'detox' or 'toxin release', so treat that framing with caution

This includes patients receiving intramuscular injections (typically 1,000 micrograms) for pernicious anaemia or documented B12 deficiency, as well as individuals taking high-dose oral supplements exceeding the Reference Nutrient Intake (1

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This is because a link between CKD and CVD exists from the early stages of the disease