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In vitro, astrocytes derived from induced pluripotent stem cells obtained from patients with FTD-MAPT showed hypertrophy, elevated GFAP protein levels, disease-associated changes in TAU expression, increased vulnerability to oxidative stress, and protein ubiquitination 231

Aug 28, 2024 5 min read 1930 views , , (, ) ,

doi: 10.1093/jn/134.3.489 [DOI] [PubMed] [Google Scholar] 3.Heitzer T, Schlinzig T, Krohn K, Meinertz T, Munzel T

PDI has two active sites, both of which are characterized by the presence of a CGHC motif, which either forms a disulphide for the enzyme to become active as an oxidase, or a dithiol for the enzyme to act as an isomerase