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Supplements Because of the link between lipoatrophy and mitochondrial damage, some people seek to prevent or reverse mitochondrial damage by taking a combination of: a potent multivitamin that includes the whole B complex of vitamins and a broad spectrum of antioxidants (vitamin C, carotenoids, selenium and others) acetyl-L-carnitine (500 mg, three times daily with meals) A separate supplement of N-acetyl-cysteine (NAC

The methods were carried out in accordance with the approved guidelines

Figure 9 In addition, to the interactive effect of sex and APOE described above there were strong sex effects observed on L-carnitine gut metabolites, and other TMA-containing metabolites, and acylcarnitines in the plasma,brain, and liver (Supplementary Table S7)