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The antidiabetic drugs metformin and acarbose lower fasting glucose with little risk of hypoglycemia, in contrast to drugs like sulfonylureas that directly stimulate insulin secretion
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Areas of modest interest have also been linked to areas on chromosomes 1, 6, and X.25 Thus, it is likely that DN, like melanoma, is a complex, heterogeneous trait

This is particularly important with colchicine as it is a substrate for CYP3A4 and P-gp and has a narrow therapeutic window
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