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VDAC ubiquitination orchestrated by a pathway involving the PTEN induced kinase 1 kinase and the parkin RBR E3 ubiquitin protein ligase (PARKIN) ubiquitin ligase eliminates damaged mitochondria by autophagy (80)

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Aredia F, Scovassi AI

1 Introduction Rheumatoid arthritis (RA) is a multifactorial autoimmune disease of unknown etiology mainly characterized by synovial hyperplasia, pannus formation, as well as cartilage and bone destruction, resulting in joint pain, stiffness, and swelling