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In contrast to PD1-binding antibodies, the two CTLA4 targeting antibodies, ipilimumab (PDB ID: 5XJ3) and tremeli-mumab (PDB ID: 5GGV), share similar binding epitopes effectively com-peting with the natural ligand, CD80 and CD86 (refs
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A chemical point of interest is the resistance of these monocyclic endoperoxide moieties to reduction by sodium borohydride
