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In addition, although the connection between the generation of free radicals and the pathogenesis of various diseases has been established, free radicals are often the result of developed diseases rather than the cause of their onset

10.1016/S1875-5364(18)30047-5 128 ZhaoH.LiY.ZhangY.HeW

Interestingly, studies have identified adipose tissue macrophages (ATMs) with iron-processing phenotypes, noting that a high-fat diet (HFD) promotes iron entry into adipocytes and inhibits the ability of ATMs to process iron (64)

Enzymes such as aldo-keto reductases (AKR) and glutathione transferases (GST) metabolize prostaglandins and reactive aldehydes with proinflammatory activity, as well as drugs and/or their reactive metabolites

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