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The latter Cochrane review reported that AOX supplementation in infertile men resulted in a significant increase of CPR (odds ratio (OR) 2.97, 95% confidence interval (CI) 1.91-4.63) although the level of evidence was found to be low (100)

Much of it migrated to a gray market of online vendors selling peptides as "research use only," often with no quality oversight, no sterility validation, no standardized dosing, and no medical supervision

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Hopkins PN, Toth PP, Ballantyne CM, Rader DJ