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So, DR could play an especially important role in enhancing the function of aged hippocampal oligodendrocytes to support neuronal and cognitive function by increasing GPD1 levels to increase G3PS activity as well as by increasing glycerol-3-phosphate levels for the synthesis of phospholipids, which contribute to the synthesis of myelin

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The beneficial effects of a MedDiet have also, more recently, been demonstrated in randomised controlled trials, including the large-scale Prevencin con Dieta Mediterrnea (PREDIMED) trial (Reference Estruch, Ros and Salas-Salvad11,Reference Estruch, Ros and Salas-Salvad12)

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Its sequence His-D-Trp-Ala-Trp-D-Phe-Lys-NH2 features a D-Tryptophan substitution at position 2, central to its recognition at GHS-R1a