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Ito et al., 2023) (this may be particularly relevant for the destabilization of myelin), synaptic dysfunction (Tu et al., 2014) (this includes impairment of signaling at the axo-myelinic synapse, crucial for survival of the myelinated axon

9 23 26 A recent Cochrane Review found that available studies only provide very low quality evidence that oral B 12 is as efficacious as intramuscular B 12 in improving symptoms

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