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Formulation and characterization of LNP LNP was generally comprised of 4 lipid components, i.e., ionizable lipid D-Lin-MC3-DMA (MCE, NJ, USA), distearoylphosphatidylcholine (DSPC), cholesterol and DMG-PEG 2k (Millipore Sigma, St

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Collectively, this study provides a solid foundation for future exploration into the impact of NNMTi-and diet-mediated changes to the gut microbiome in obese and lean populations, as well as future targets to investigate mechanistically with NNMTi treatment