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Chem Comm

In the second part of the review, the current evidence of the role of impaired barrier function in the pathophysiology of selected gastrointestinal and liver diseases is discussed

KU-57788 suppresses ATC tumor growth and acts synergistically with ferroptosis inducers in vivo We have revealed that KU-57788, by activating DRP1, promotes excessive mitochondrial fission and fragmentation in ATC cells, and activates the NRF2/SLC7A11/GSH axis to protect against cell death, while also suggesting that KU-57788 can act as a synergist in ferroptosis

Moreover, GST has a high affinity toward reduced Glutathione, its natural substrate

[DOI] [PMC free article] [PubMed] [Google Scholar] 219.Qiu Z., He Y., Ming H., Lei S., Leng Y., Xia Z.Y