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Gynecologists are particularly wary of pigmented lesions of the vulva because the prognosis for vulvar melanoma is poor due to the tendency for increased tumor thickness at the time of presentation

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That nuclear translocation under metabolic stress is documented in the published literature: a peer-reviewed study in Cell Metabolism demonstrating that MOTS-c translocates to the nucleus to regulate nuclear gene expression in response to metabolic stress in an AMPK-dependent manner describes the exact mechanism