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ClinicalTrials.gov (2022)

As cannabis becomes legalized and more widely accepted, and as we understand that you can be tolerant and have physical or psychological withdrawal from many medicines without necessarily being addicted to them (such as opiates, benzodiazepines, and some antidepressants), I think this definition seems obsolete and overly inclusive

Sheeja Malar, D., Beema Shafreen, R., Karutha Pandian, S

Twenty were linked to three disrupted pathways: (1) phenylalanine metabolism and related biosynthesis, (2) arachidonic acid metabolism and (3) unsaturated fatty acid biosynthesis