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doi: 10.1016/j.bbrc.2006.04.003

Additionally, microglia, the brains resident immune cells, exhibit a metabolic flexibility that allows them to shift between oxidative phosphorylation and glycolysis, depending on their activation state, which significantly influences neuroinflammation and synaptic plasticity

Now, maybe you dont need that boost if you dont have as much damage

Excess Cu ions have been shown to induce COX17 expression [53] and Cd toxicity can increase CCH transcripts [54], two genes encoding Cu chaperone proteins

Additional adverse reactions, some of which may be serious, may become apparent with more widespread use of the Pfizer-BioNTech COVID-19 Vaccine