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Polyclonality of BRAF mutations in acquired melanocytic nevi
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As rats on the fcHF diet lacked the sugar component and consumed more calories from fat compared to rats on the fcHFHS diet, and fat intake was the most inhibited after MTII administration, these data point toward an important role for diet composition and particularly the fat content in the diet in sensitivity to melanocortins
In human trials, however, the risk for muscle fiber necrosis should be monitored carefully and explored further
