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This toxicity is the Acetaminophen is metabolized in two ways

GSH and iron homeostasis GSH also protects against ferroptosis through coupling with iron homeostasis
In AD, Tau A152T -induced glutamatergic neuron loss is mainly caused by necrosis, which disrupts lysosomal catabolic aspartic protease cathepsin D activity [121]

10.1002/dneu.20996 Dev

This suggests that GF-HLCs attain a level of hepatic differentiation that is synonymous with PHHs
