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An Iranian pilot study (2010, n=35) compared 600 mg silymarin daily with 30 mg fluoxetine over 8 weeks
It also upregulates molecular chaperones and components of the proteostasis network, such as heat shock proteins (HSP60, HSP70) and autophagy-related proteins, facilitating the removal of toxic protein species (75)

In the co-culture system, MCECs derived from the model group exhibited significant reduced ZO-1 and Occludin expression compared to those from the Control group, whereas GHK-Cu elevated theses protein levels (Figures 4GI)

During drug and alcohol detox, oxidative damage and inflammation are heightened
