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Despite good antitumor activity, DON has multiple targets and some side effects such as nausea and vomiting (Cervantes-Madrid et al., 2015

To avoid such side effects, the VIC supplementation should not exceed the tolerable upper intake levels (Table 2)

Epub 2016 May 7

10.1016/j.arr.2023.101993 277 YangK.XuJ.FanM.TuF.WangX.HaT.et al (2020)

In view of these reported differences in effects of Cannabis sativa as regards depression, the aim of the study was to: (1) examine the effect of cannabis in the forced-swim test (a test for depressive-like behavior) (Porsolt et al., 1978) in normal mice and after treatment with the selective serotonin reuptake inhibitors (SSRIs) fluoxetine and sertraline as well as the tri-cyclic drug imipramine with view to a possible modulatory effect of antidepressant drugs