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Heather NL, Jefferies C, Hofman PL, Derraik JG, Brennan C, Kelly P, Hamill JK, Jones RG, Rowe DL, Cutfield WS

An imbalance between SOD activity and GPX was proposed as an important determinant of molecular ageing, since the resultant hydroxyl radicals which are highly reactive could cause damage to macromolecules such as DNA, protein and lipids (Bar-Peled, Korkotian, Segal & Groner, 1996

The conversion of a cysteine S-conjugate to the corresponding alpha-keto acid occurring by transamination with a suitable alpha-keto acid acceptor has already been observed for other compounds conjugated to NAC ( 27 )