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Targeting the insulin-like growth factor 1 receptor (IGF1R) signaling pathway for cancer therapy

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Mitochondrial stabilization and accumulation of PINK1 can occur due to the over expression of misfolded proteins in the mitochondrial matrix

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The direct cytotoxic effects on renal TECs, promotion of oxidative stress, and association with ferroptosis highlight the deleterious role of MG in exacerbating renal injury
