glutathione-mediated detoxification Conjugation of Anticancer Drugs: An Overview of Reaction Mechanisms and Biological Significance for Drug and Bioactivation Regulation of Xenobiotics in Higher

Resolving these challenges through innovative delivery technologies, precision targeting motifs, and model systems that accurately mirror human CL metabolism will be pivotal in determining whether cardiolipin-focused interventions can mature into effective complements to broader mechanistic strategies

doi:10.1096/fj.201901363RRR 9

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RSL3, a compound containing an electrophilic moiety and a chloroacetamide moiety, could reacted with the nucleophilic amino acid residue at the active site of GPX4

However, there are a small but very important group of patients who cannot tolerate these present agents