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Following pre-fractionation of trypsinized proteins by strong cation exchange (SCX) chromatography, pS-MIP enrichment led to the identification of 924 phosphopeptides in the HEK 293T whole-cell lysate, exceeding the number identified by TiO 2 -based enrichment (230)

Notably, ALR degradation via ubiquitination exacerbates mitochondrial fission, promoting the progression from NASH to HCC

Weinhold LC, Ahmad S, Pardini RS

Mechanistically, ALA may support lipid metabolism through several pathways:60 Reduces oxidative stress in liver cells ALA works as an antioxidant by neutralizing reactive oxygen species (ROS) unstable molecules that can damage liver cells and interfere with fat metabolism

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