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This powerful antioxidant delivered intravenously provides nearly 100% bioavailability compared to oral supplements that break down in the digestive tract

133 Further, in vitro studies using human cell lines have shown that acetaminophen can cause an immediate, reversible, dose-dependent loss of oxygen uptake followed by a slow, irreversible, dose-independent death and have suggested mechanisms by which acetaminophen may cause toxicity in tissues other than the liver

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In other words, smaller daily doses are better than infrequent higher ones