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It is important to note that all current evidence derives from in vitro cellular models and in vivo animal studies, and no human clinical trials have been conducted as of February 2026

Bioorg Med Chem Lett

doi: 10.1016/s0959-440x(02)00391-3

Tesofensine was originally developed by a Danish biotechnology company, NeuroSearch, who transferred the rights to Saniona in 2014

But here is the limitation that makes the AOD 9604 combination appealing
