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It characterizes these trials and analyzes the application of DHTs across multiple stages of study process, highlighting their functional roles, technological diversity, and opportunities for future improvements

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Here, persistent, albeit often lowgrade, peripheral nociceptive input (e.g., from OA, tendinopathy) acts as the primary driver, initiating and maintaining central amplification

The combination of GSH or NAC with LLP-1 prevented the mitochondrial membrane depolarization and cell death [25]

Dietary management based on anti-inflammatory principles has also recently been utilized as a recommended therapy to reduce immunosuppressive agent-induced adverse effects [125]