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May 15 2017;132:1-8

When you use AHK-Cu, you are introducing a novel compound that your body did not evolve to expect

Although the cytochrome P450 enzyme system is present, its activity is relatively lower compared with the gastrointestinal tract

A subsequent 2014 paper by Chang and colleagues in Molecules showed that BPC-157, applied at 0.10.5 g/mL in vitro, dose- and time-dependently upregulated growth hormone receptor expression at both mRNA and protein levels in cultured rat Achilles tendon fibroblasts a mechanistic in vitro finding for which numeric fold-changes and p-values are not reported in the abstract

The condition must be confirmed by genetic testing demonstrating variants in POMC, PCSK1, or LEPR genes that are interpreted as pathogenic, likely pathogenic, or of a variant of uncertain significance (VUS)