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However, their persistence in the environment raises serious toxicological concerns, such as lung toxicity (inflammation, fibrosis, and respiratory dysfunction), skin toxicity (allergic reactions and dermatitis), liver damage (oxidative stress and lipid peroxidation), kidney toxicity (nephrotoxicity and filtration interference), and cardiovascular problems (endothelial dysfunction and arterial plaque formation)

Additionally, a subset of CRC cells can enter a quiescent state under chemotherapeutic stress, giving rise to drug-tolerant persister cells (DTPs) [62]

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doi: 10.3389/fimmu.2020.623691 43 HsuC