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252 Here we review the impact of metal promiscuity and crosstalk in the context of structural and sequence determinants of metal specificity and allosteric connectivity for four classes of metal efflux regulators (ArsR, MerR, CopY, and CsoR), four families of uptake regulators (Fur, DtxR, NikR, and Rrf2) and finally, four families within which metallosensors are significantly under-represented (TetR, MarR, LysR and GntR)

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