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OIS acts as a safeguard against the development of cancer by halting the growth of potentially malignant cells.14 In other words, oncogenic activation (eg, RAS, RAF, and MYC) can induce senescence as a protective mechanism against uncontrolled proliferation

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Many intrinsic and extrinsic factors, such as neurotrophic factors, transcription factors, cell cycle regulators, cell proliferation, neurogenic niche and differentiation into mature neurons, play an important role in the pathomechanism of AD

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