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(288) demonstrated significantly reduced abundance of Akkermansia muciniphila in the intestines of DKD patients and db/db mice [Human observational + animal model evidence]
On one hand, ROS can directly induce damage to mtDNA damage by oxidative modification of mtDNA bases

Science 356:1246 Qadir A, Hashmi MZ, Mahmood A (2017) Xenobiotics, types, and mode of action

(2023) Antiproliferative activity of antimicrobial peptides and bioactive compounds from the mangrove Glutamicibacter mysorens

However, most research points to the most pronounced diuretic effects in people who dont consume caffeine regularly
