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Reactive oxygen species (ROS), particularly hydrogen peroxide (H 2 O 2 ), strongly potentiate NF-B activation by stimulating redox-sensitive upstream kinases such as TAK1 and inhibiting phosphatases including PP2A, thereby accelerating IB degradation and nuclear signaling (Vainshtein and Sandri, 2020) (Zhang H

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Findings suggest that trazodone is less addictive than the other two drugs in the study, yet it is still misused and can cause physical dependence, especially when used for a long period

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