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Antibodies with a preferential role in ADCs must have the following characteristics: special targeting ability to deliver cytotoxic drugs to the tumor cells, high affinity binding to tumor cell-surface antigens and the ability to induce the cells endocytosis, low immunogenicity and the appropriate linkage sites which would not impact the affinity, endocytosis or efficacy of cytotoxic drugs [32]

Research in dogs with liver disease has documented altered liver glutathione concentrations, supporting the idea that antioxidant systems may be under different pressure in hepatic conditions

It has been shown that an exogenous addition of GSH could effectively reduce radiation-induced micronuclei [33] and chromosome aberrations in different systems [34], including the muntjac lymphocyte cultures [35]

doi: 10.1155/2021/9914652 159 YangX

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