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Abbreviations AJCC: American Joint Committee on Cancer ATF1: Activating transcription factor 1 CK: Cytokeratin CCMT: Clear cell myomelanocytic tumor CCSST: Clear cell sarcoma of soft tissues CREB1: CAMP-response element binding protein EWSR1: Ewing sarcoma breakpoint region 1 FISH: Fluorescence in situ hybridization FLI1: Friend leukemia integration 1 GCT-TS: Giant cell tumor of the tendon sheath HMB45: Human melanoma black 45 IHC: Immunohistochemistry MiTF: Microphthalmia-associated transcription factor MM: Malignant melanoma MPNST: Malignant peripheral nerve sheath tumor MRI: Magnetic resonance imaging NSE: Neuron specific enolase PAS: Periodic acid Schiff PLDM: Paraganglioma-like dermal melanocytic tumor PVNS: Pigmented villonodular synovitis RT-PCR: Reverse transcriptase polymerase chain reaction SMA: Smooth muscle actin TGCT: Tenosynovial giant cell tumor References Malchau SS, Hayden J, Hornicek F, Mankin HJ

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Normally, more than 99% of stored enzyme is secreted into the pancreatic duct and less than 1% diffuses across cell membranes and reaches the circulation via lymphatics and capillaries

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The result is enhanced production of eumelanin, the brown-black pigment responsible for tanning

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