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Thesignsandsymptomsof thedeficiencymay include anemia , the buildup of too much acid in the body (metabolic acidosis), frequent infections, andsymptomscaused by problems in the brain including seizures , intellectual disability , and loss of coordination ( ataxia )

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The bloodbrain barrier (BBB) and blood-cerebrospinal fluid barrier protect the central nervous system against toxins and are the most significant barriers to effective brain drug delivery in managing Parkinsonism

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