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In a recent study in liver cirrhosis of any cause, not only urinary 51 Cr-EDTA excretion was elevated in about half the patients and associated with Child-Pugh state, it was also present in all ascites samples from patients with spontaneous bacterial peritonitis (SBP) (143)

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Specifically, the binding of IGFBP3 to GRP78 increases autophagic site formation and autophagic system flux, thereby promoting breast cancer cell survival even under glucose starvation and hypoxic conditions (57)
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GPX4 depletion alone is not a definitive indicator of ferroptosis, as it is also implicated in alternative cell death pathways, thereby requiring supplementary markers for accurate identification
