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There is also some limited evidence suggesting that individuals who carry certain polymorphisms in genes involved in vitamin C transport and detoxification mechanisms may have lower plasma vitamin C concentrations even with high vitamin C intakes (see also Vascular complications of diabetes mellitus) (reviewed in 27)

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LY294002, a PI3K inhibitor, blocked PI3K/Akt signaling in osteoblasts and inhibited cell proliferation, ALP activity, calcium accumulation, and expression of osteogenic markers, indicating that the PI3K/Akt pathway is essential for osteoblast function and mineralized bone formation is critical (Zhou et al., 2019)