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Glutaminase 2 is a novel negative regulator of small GTPase Rac1 and mediates p53 function in suppressing metastasis

A clearly recognized function of GSTs is their participation in antioxidative reactions together with the pivotal cellular antioxidant GSH in order to eliminate ROS and lipid hydroperoxides that accumulate in infected tissues (Figure 1) (Wagner et al., 2002)

Downregulation of DDIT4 ameliorates abnormal behaviors in autism by inhibiting ferroptosis via the PI3K/Akt pathway

During ischemia, reduced oxygen supply impairs ATP production, disrupts cellular integrity, and causes ionic imbalances, leading to cellular damage

This review aims to provide current insights into the development and potential use of heterocyclic compounds targeting diverse therapeutic targets to manage and potentially treat patients with AD and PD