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Decreasing the liberation of glutamate from the glutathione cycle leads to decreased cortical neuron glutamate, while decreasing the utilization of glutamate increases total glutamate by about 25%

Gharipour M, Sadeghi M, Behmanesh M, Salehi M, Nezafati P, Gharipour A (2017) Selenium homeostasis and clustering of cardiovascular risk factors: a systematic review

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Cystine is largely insoluble, which makes its effective reduction an essential requirement in vivo