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Zhang B, Guo Y
doi: 10.1038/nrn2421
Possibly, high conversion rates of O 2 to H 2 O 2 via SOD necessitates further processing of H 2 O 2 by high GPX activity
The paradox of the remethylation block theory is thus that hyperhomocysteinemia ought to be protective toward GSH, or in other words, that vitamin B 12 deficiency actually has antioxidant benefit

For deeper context on metabolic signaling, GLP-1 and gut microbiome research may help explain why appetite regulation, inflammation, and microbial balance are often discussed together during menopause
