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A dose that produces an effect in a mouse does not scale linearly to a human by body weight, and the research doses in this protocol are practitioner-derived conventions, not figures validated against human outcomes

By contrast, semaglutide alone yielded 14.8% of patients achieving 25% weight loss, and cagrilintide alone yielded 6.5%

Key takeaway: Suggests possible relevance for joint and connective tissue research

Institutional Review Board Statement All procedures and manipulations with animals were approved by the Committee for Control over Care and Use of Laboratory Animals of BIBCh RAS and were carried out in accordance with the EU Directive 2010/63/EU for animal experiments and Animal Control and Use Committee (IACUC), protocol number 683/19, 27 February 2019

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