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Twenty-four WT and twenty-four RAMP1/3 KO male mice were fed a 60% HFD for 18 weeks followed by a 45% HFD for six weeks

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These findings shed new light on a potential treatment for LOH

The primary endpoint was time to first acute exacerbation, with secondary endpoints including acute exacerbation frequency, sputum and serum NSP activity levels, quality of life scores, and safety indicators