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PMID: 35383604

Among RNS molecules, peroxynitrite, a product of superoxide anion and nitric oxide, is one of the most prominent one ( Studies have shown that organisms can activate a series of defense responses, such as improving the activity of antioxidant enzymes in the body and initiating lysosomal degradation pathways, to prevent oxidative damage

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Nuclear factor erythroid 2-related factor (Nrf2) transcription factor/Heme oxygenase 1 (HO-1, encoded by Hmox1 gene) is an essential antioxidant signaling pathway that protects against inflammation, apoptosis, and oxidative stress (Upadhayay and Mehan, 2021)