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It suffers from bioavailability issues, and the CNS-targeting theory remains unvalidated for this specific compound

Compared with the rats treated with APAP alone, rhein treated animals demonstrated significant reduction of the biochemical indicators of liver injury, including aspartate aminotransferase (AST), alanine aminotransferase (ALT), urea nitrogen (UREA), creatinine (CREA), nitric oxide (NO), and malondialdehyde (MDA)

It is not a drug, supplement, or medical product and is not approved for human or animal use, diagnosis, or treatment

Chemical Papers

Peptides are also used in some FDA-approved medications to treat diabetes, obesity, certain endocrine disorders, and other health conditions