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BBB and SAE Sepsis, a pathological process causing dysfunction of ones own organs due to bacterial infection and its resulting dysregulated inflammatory response, is the leading cause of death in critically ill patients with significant morbidity and mortality, representing a high proportion of readmissions after treatment discharge (Fleischmann et al., 2016a

The threshold Glide XP score and MMGBSA binding affinity values were set at -8 and -60 Kcal/mol respectively (based on docking scores with the substrate, glutathione) for the final screening of compounds

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