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Activation of the BDNF pathway is well-known to increase dendritic spine growth and axonal connectivity, both of which are crucial mechanistic underpinnings of learning

Previous studies have revealed that a deficiency B12 is associated with cognitive decline or Alzheimer disease

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Comparisons between the pill group and patch group found that people in the patch group were more likely to have nutritional deficiencies, including vitamins B1, B12, and D
One reason: Changes in stomach acid can be part of aging, and you need hydrochloric acid in your stomach to absorb B12
